Anti-Inflammatory Painkiller Drugs and Arthritis From the Cleveland Clinic

How Do NSAIDs Work?

NSAIDs work by blocking the production of certain chemicals in the body that cause inflammation.

Do All NSAIDs Work the Same Way?

There appears to be no fundamental difference in the ability of different NSAIDs to reduce pain and inflammation. However, you might find that you get more relief from one NSAID over another and some NSAIDs may have fewer side effects than others. Some NSAIDs also may be more convenient for people, since they only need be taken once or twice a day.

What Are the Common Side Effects of NSAIDs?

Although NSAIDs are reasonably safe medications, it is important that you are aware of potential side effects. In 2005, the FDA asked makers of NSAIDs to revise their labels to include more specific information on risks including potential heart attack, stroke, stomach bleeding.

NSAIDs are safest when low doses are taken for brief periods. Side effects most commonly occur if you are taking large doses over a prolonged time (months or years). Some side effects are mild and go away on their own or after reducing the dose. Others may be more serious and need medical attention.

Common side effects of NSAIDs include:

• Stomach pain and heartburn
• Stomach Ulcers.
• General bleeding tendency increases while taking NSAIDs, especially aspirin. Your doctor might tell you to stop NSAIDs before surgery. Ask your doctor before taking NSAIDs if you are on blood-thinning medications (such as Coumadin).
• Headaches and dizziness.
• Ringing in the ears may result from certain NSAIDs, including aspirin. This can usually be eliminated by decreasing the dose.
• allergic reactions such as rashes, wheezing, and throat swelling
• Liver or kidney problems. These problems can be evaluated by blood tests in people who take NSAIDs for prolonged periods. People with any kidney problems should not take NSAIDs without checking with their doctor.
• High blood pressure
• Leg swelling

Please note: The side effects listed are the most common ones. All possible side effects are not included. Always contact your doctor if you have questions about your particular medication or if you are experiencing any unusual side effect.

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